TL;DR
- Complete Act 2’s Lethe National Library puzzle to obtain the Twin-Headed Serpent artifact
- Return to Vyssa Hills and use the artifact on the Serpent Door near the Timeloop rift
- Collect the Mine Key with Moon symbol and follow mouse drawings through the mines
- Navigate to upper ridges and use ladders to access hidden mine sections
- Unlock gates and follow tunnels to discover critical quest items and progression paths
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Many players encounter the Vyssa Hills Serpent Door early in their Hell Is Us journey, only to discover this mysterious stone barrier remains sealed until significant campaign progression occurs. The door’s intricate serpent carvings hint at its importance, yet accessing what lies beyond requires specific preparation and timing that new adventurers often underestimate.
This particular Serpent Door adjacent to the Timeloop rift serves as a classic gating mechanism, designed to prevent premature access to later-game content. You’ll need to advance through Act 2’s main storyline before this pathway becomes available. The developers intentionally placed this obstacle to ensure players develop necessary skills and acquire critical tools before facing more challenging environments.
The essential requirement involves obtaining a special artifact called the Twin-Headed Serpent, which functions as both key and ceremonial object. This item represents one of the game’s more complex puzzle rewards, requiring methodical problem-solving rather than combat prowess. Understanding this progression system early can save hours of frustration attempting to bypass what cannot be circumvented through conventional means.
Successfully completing the Lethe National Library Puzzle yields the Twin-Headed Serpent as your well-earned prize. This multi-stage intellectual challenge tests your environmental observation skills and pattern recognition abilities rather than reaction times. The library’s archives contain subtle clues about Vyssa Hills’ history that become relevant later in your exploration.
Once you possess this ancient artifact, journey back to the Vyssa Hills region where the sealed doorway awaits. The stone slot mechanism responds only to this specific object, rejecting any attempts at substitution or force. Carefully align the Twin-Headed Serpent with the receptacle, watching as the massive stone structure grinds open to reveal previously inaccessible terrain.
The revealed passage leads to an enclosed area containing immediately useful resources. Your first priority should be collecting the glowing Mine Key marked with the Moon symbol, located conveniently near a door bearing matching lunar imagery. This key becomes essential for deeper mine exploration and represents your next major objective.

Your current mission shifts to locating another vital quest item hidden within the mine’s labyrinthine tunnels. Begin by retracing your steps to the upper ridges area, specifically the location where you first encountered Tania during the campaign’s earlier hours. This reunion with familiar geography provides orientation before descending into unfamiliar underground complexes.
Scale the ladder in this region and conduct a thorough visual sweep of your surroundings. You’ll notice a modest hut structure that may have previously escaped your attention. Investigate this building to discover an additional ladder descending into the mine’s deeper sections, bypassing more treacherous surface routes.
Upon reaching the subterranean passageways, immediately scan left to identify a secured gate blocking further advancement. Nearby, you’ll observe a slightly faded illustration depicting a white mouse—this artwork serves as the first in a series of navigational markers.

Utilize your acquired Mine Key to unlock this barrier, then proceed cautiously through the interconnected tunnels. Maintain constant vigilance for additional mouse drawings adorning the walls—these function as a primitive but effective guidance system leading toward your objective. The final marker precedes another ladder providing egress back to surface levels and continued adventure.


Seasoned players recommend documenting each mouse drawing’s location, as backtracking through identical-looking tunnels can become disorienting. The illustrations follow a logical sequence when understood, with each mouse positioned to indicate direction changes or hidden switches. Missing just one marker could lead to extensive unnecessary exploration.
A common mistake involves attempting the Lethe Library puzzle prematurely without acquiring necessary context clues from earlier missions. The library’s architectural patterns mirror symbols found in Vyssa Hills, creating connections observant players can leverage for faster completion.
Time optimization suggests completing the library challenge and Serpent Door sequence in a single gaming session, as the spatial memory retention significantly reduces mine navigation time. Allocate approximately 45-60 minutes for the entire process from puzzle start to mine exit.
For those struggling with spatial awareness, the Complete Guide offers broader navigation principles applicable across multiple gaming environments. The mine’s design incorporates verticality that many modern games utilize, including the mechanics discussed in our Class Guide for tactical positioning.

Advanced players should note the Mine Key’s compatibility with other lunar-marked doors throughout the region, potentially unlocking shortcuts or hidden caches. This interconnectivity reflects the developers’ commitment to rewarding thorough exploration beyond main storyline progression.

Equipment selection proves crucial for mine navigation—ensure you’ve consulted our Weapons Unlock guide for optimal loadouts when facing unexpected subterranean encounters. The strategic principles transfer well between different gaming scenarios.
Action Checklist
- Complete Act 2 and solve Lethe National Library puzzle to obtain Twin-Headed Serpent
- Return to Vyssa Hills and insert artifact into Serpent Door slot
- Collect Mine Key with Moon symbol from newly revealed area
- Navigate to upper ridges and locate hut with descending ladder
- Follow mouse drawing markers through mines to locate quest items
No reproduction without permission:SeeYouSoon Game Club » How To Open The Vyssa Hills Serpent Door In Hell Is Us Complete guide to unlocking the Vyssa Hills Serpent Door and navigating the mines in Hell Is Us
